Synthesis and mannosidase inhibitory activity of 3-benzyloxymethyl analogs of swainsonine

被引：79

作者：

Pearson, WH ^{[1
]}

Guo, LY

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 47期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(01)01777-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Swainsonine (3), an inhibitor of Golgi alpha -mannosidase II, is a clinical candidate for cancer treatment. In order to avoid potential problems arising from its co-inhibition of lysosomal mannosidases, we have synthesized 3-benzyloxymethyl analogs of swainsonine (17 and 18). Initial screening of these new compounds is reported. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：8267 / 8271

页数：5

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