OPINION Direct electrical stimulation of human cortex - the gold standard for mapping brain functions?

被引:288
作者
Borchers, Svenja [1 ]
Himmelbach, Marc [1 ]
Logothetis, Nikos [2 ,3 ]
Karnath, Hans-Otto [1 ,4 ]
机构
[1] Univ Tubingen, Ctr Neurol, Div Neuropsychol, D-72076 Tubingen, Germany
[2] Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany
[3] Univ Manchester, Dept Imaging Sci & Biomed Engn, Manchester M13 9PT, Lancs, England
[4] Univ S Carolina, Dept Psychol, Columbia, SC 29208 USA
基金
欧洲研究理事会;
关键词
PYRAMIDAL TRACT CELLS; CAT VISUAL-CORTEX; MOTOR CORTEX; INTRACORTICAL MICROSTIMULATION; INDIRECT ACTIVATION; MOVEMENT INTENTION; SIGNAL PROPAGATION; CORTICAL-NEURONS; CEREBRAL-CORTEX; NERVOUS-SYSTEM;
D O I
10.1038/nrn3140
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Despite its clinical relevance, direct electrical stimulation ( DES) of the human brain is surprisingly poorly understood. Although we understand several aspects of electrical stimulation at the cellular level, surface DES evokes a complex summation effect in a large volume of brain tissue, and the effect is difficult to predict as it depends on many local and remote physiological and morphological factors. The complex stimulation effects are reflected in the heterogeneity of behavioural effects that are induced by DES, which range from evocation to inhibition of responses - sometimes even when DES is applied at the same cortical site. Thus, it is a misconception that DES - in contrast to other neuroscience techniques - allows us to draw unequivocal conclusions about the role of stimulated brain areas.
引用
收藏
页码:63 / 70
页数:8
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