Aberrant microRNA expression pattern in myelodysplastic bone marrow cells

被引：53

作者：

Hussein, Kais ^{[1
]}

Theophile, Katharina ^{[1
]}

Buesche, Guntram ^{[1
]}

Schlegelberger, Brigitte ^{[2
]}

Goehring, Gudrun ^{[2
]}

Kreipe, Hans ^{[1
]}

Bock, Oliver ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Pathol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 09期

关键词：

microRNA; Expression profile; Myelodysplastic syndrome; MDS; del(5q); -7; +8; Bone marrow cells; ACUTE MYELOID-LEUKEMIA; DELETED REGION; GENE; IDENTIFICATION;

D O I：

10.1016/j.leukres.2010.04.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n = 12) and distinct cytogenetic aberrations (n = 12). In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), -7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1169 / 1174

页数：6

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