VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome

被引：38

作者：

Niimi, H ^{[1
]}

Arimura, K ^{[1
]}

Jonosono, M ^{[1
]}

Hashiguchi, T ^{[1
]}

Kawabata, M ^{[1
]}

Osame, M ^{[1
]}

Kitajima, I ^{[1
]}

机构：

[1] Kagoshima Univ, Dept Internal Med 3, Kagoshima 8908520, Japan

来源：

INTERNAL MEDICINE | 2000年 / 39卷 / 12期

关键词：

IL-1; beta; 1L-6; TNF-alpha; thiamine; prednisolone; argatroban;

D O I：

10.2169/internalmedicine.39.1101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH), In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1 beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF, Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.

引用

页码：1101 / 1104

页数：4

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