Microwave-assisted asymmetric intermolecular heck reaction Using phosphine-thiazole ligands

被引：33

作者：

Kaukoranta, Paivi ^{[1
]}

Kallstrom, Klas ^{[2
]}

Andersson, Pher G. ^{[1
]}

机构：

[1] Dept Biochem & Organ Chem, S-75123 Uppsala, Sweden

[2] Biovitrum AB, S-11276 Stockholm, Sweden

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 17-18期

关键词：

asymmetric catalysis; Heck reaction; microwave heating; phosphine-thiazole ligands;

D O I：

10.1002/adsc.200700390

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of new phosphine-thiazole compounds has been synthesized and used as efficient ligands in the palladium-catalyzed asymmetric intermolecular Heck coupling of 2,3-dihydrofuran with aryl triflates and cyclohexenyl triflate. Microwave heating was used to accelerate the reactions and gave complete conversions in as little as one hour. Products were obtained with good to excellent enantioselectivities.

引用

页码：2595 / 2602

页数：8

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