The application of HETPHOX ligands to the intramolecular asymmetric Heck reaction

被引：13

作者：

Fitzpatrick, Martin O. ^{[1
]}

Coyne, Anthony G. ^{[1
]}

Guiry, Patrick J. ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Chem & Chem Biol, Conway Inst Biomol & Biomol Res, Ctr Synth & Chem Biol, Dublin 4, Ireland

来源：

SYNLETT | 2006年 / 18期

关键词：

Heck reaction; asymmetric catalysis; ligands; oxazolines; palladium;

D O I：

10.1055/s-2006-951500

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new thiophene-oxazoline P,N ligand derived from cisaminoindanol was prepared and a range of analogous HETPHOX ligands were applied to the intramolecular Heck reaction. The enantioselectivity obtained was 76% employing the tert-butyl-substituted HETPHOX ligand with an aryl triflate spirooxindole precursor. The isomer distribution of the product spirooxindoles was high (up to 99: 1).

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收藏

页码：3150 / 3154

页数：5

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