HetPHOX: a new class of easily prepared modular chiral ligands

被引：13

作者：

End, N

Stoessel, C

Berens, U

di Pietro, P

Cozzi, PG

机构：

[1] Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] Ciba Specialty Chem, Grp Res, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 14期

关键词：

D O I：

10.1016/j.tetasy.2004.06.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of a new class of modular chiral phosphino-oxazoline ligands containing the diphenylphosphino group at different positions of the heterocyclic backbone is described. HetPHOX ligands were tested in enantioselective allylations and in transfer hydrogenation reactions. The synthesis of the ligands is facile with high enantioselectivity (99% ee) obtained in the Pd-catalyzed addition of malonate to diphenylallyl acetate using ligand 10. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：2235 / 2239

页数：5

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