New sesquiterpenoids isolated from Atractylodes lancea fermented by marine fungus

被引：37

作者：

Kamauchi, Hitoshi ^{[1
]}

Kinoshita, Kaoru ^{[1
]}

Takatori, Kazuhiko ^{[2
]}

Sugita, Takashi ^{[3
]}

Takahashi, Kunio ^{[1
]}

Koyama, Kiyotaka ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, Kiyose, Tokyo 2048588, Japan

[2] Meiji Pharmaceut Univ, Dept Synthet Organ Chem, Kiyose, Tokyo 2048588, Japan

[3] Meiji Pharmaceut Univ, Dept Microbiol, Kiyose, Tokyo 2048588, Japan

来源：

TETRAHEDRON | 2015年 / 71卷 / 13期

关键词：

Fermentation; Diversity; Atractylodes lancea; Marine fungi; Sesquiterpenoid;

D O I：

10.1016/j.tet.2015.02.041

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

The diversity of natural compounds is extensive but not unlimited. Fermentation of rhizomes of Atractylodes lancea by marine fungus (Cladosporium cladosporioides) enhanced the diversity of natural compounds. From the fermented rhizomes of A. lancea, two new spirovetivane-type sesquiterpenoids, 2-oxo-12-hydroxy-hinesol (1) and 2-oxo-15-hydroxy-hinesol (2); a new guaiane-type sesquiterpenoid atractylol A (3); and three new eudesmane-type sesquiterpenoids, 14-hydroxy-isopterocarpolone (4), 3 alpha-hydroxy-pterocarpol (5), and (11R)-2, 11, 12-trihydroxy-beta-selinene (6), were isolated along with known sesquiterpenoids (7-10). The structures of these compounds were established using NMR, MS, and IR methods. These compounds (1-6) were not observed in A. lancea extracts by TLC and HPLC analysis, suggesting that these compounds were generated during the fermentation process. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1909 / 1914

页数：6

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