Development of Diversity-Enhanced Extracts of Curcuma zedoaria and Their New Sesquiterpene-like Compounds

被引：48

作者：

Kikuchi, Haruhisa ^{[1
]}

Sakurai, Kazuyoshi ^{[1
]}

Oshima, Yoshiteru ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 07期

关键词：

CHEMICALLY ENGINEERED EXTRACTS; VETIVANE SESQUITERPENES; NATURAL-PRODUCTS; DRUG DISCOVERY; BETA-VETIVONE; CONSTITUENTS; BIOACTIVITY; CYCLIZATION; FRAMEWORK; STRATEGY;

D O I：

10.1021/ol5004324

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Through the combination of natural products chemistry and diversity-oriented synthesis, a new approach, diversity-enhanced extracts, for increasing the diversity of natural product-like compounds is proposed. They are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. This method was applied to terpenes extracted from Curcuma zedoaria. Epoxidation and subsequent ring-opening reactions of epoxides were used to modify molecular skeletons. As a result, seven sesquiterpene-like compounds with some containing new molecular skeletons were obtained.

引用

页码：1916 / 1919

页数：4

共 34 条

[1]

[Anonymous], 2001, TETRAHEDRON ASYMMETR

[2]

Unnatural natural products from the transannular cyclization of lathyrane diterpenes [J].