Antimycobacterial matricaria esters and lactones from Astereae species

被引：27

作者：

Lu, TS

Cantrell, CL

Robbs, SL

Franzblau, SG

Fischer, NH ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[2] US Dept Hlth & Human Serv, Lab Res Branch, GWL Hansens Dis Ctr, Baton Rouge, LA USA

来源：

PLANTA MEDICA | 1998年 / 64卷 / 07期

关键词：

D O I：

10.1055/s-2006-957547

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six matricaria esters (MEs) and two matricaria lactones (MLs), isolated from members of the tribe Astereae (Asteraceae), were tested against Mycobacterium tuberculosis and M. avium, using a radiorespirometric bioassay. (ZZ,8Z)-ME and (ZE-8Z)-ME gave minimum inhibitory concentrations (MICs) of 50 mu g ml(-1) against M. tuberculosis and respective MICs of 25 and 50 mu g ml(-1) against M. avium. The (4Z,8Z)-ML, (2Z)-8-dehydro-ME and (2Z,8Z)-10-angeloyloxy-(2Z.8Z)-ME showed respective MICs of 12.5, 25, 25 mu g ml(-1) against M. tuberculosis and MICs of 50, 25, 25 mu g ml(-1) against M. avium, respectively. The MICs of (2Z-8Z)-10-tigloyloxy-ME and (2E,8Z)-10-angeloyloxy-ME and (4E,8Z)-ML ranged from 50 to > 100 mu g ml(-1) against both pathogenic mycobacteria.

引用

页码：665 / 667

页数：3

共 19 条

[1] POLYACETYLENE COMPOUNDS .253. NEW ACETYLENE-COMPOUNDS FROM CHRYSOTHAMNUS-PARRYI [J].