Modeling tissue morphogenesis and cancer in 3D

被引：1386

作者：

Yamada, Kenneth M. ^{[1
]}

Cukierman, Edna

机构：

[1] Natl Inst Hlth, Natl Inst Dental & Craniofacial Res, Lab Cell & Dev Biol, Bethesda, MD 20892 USA

[2] Fox Chase Canc Ctr, Div Basic Sci, Philadelphia, PA 19111 USA

来源：

CELL | 2007年 / 130卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three-dimensional ( 3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to accelerate translational research in cancer biology and tissue engineering.

引用

收藏

页码：601 / 610

页数：10

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共 80 条

[71] Studying actin-dependent processes in tissue culture [J].

Walpita, D ;

Hay, E .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (02) :137-141

[72] Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures:: A different perspective in epithelial biology [J].

Wang, F ;

Weaver, VM ;

Petersen, OW ;

Larabell, CA ;

Dedhar, S ;

Briand, P ;

Lupu, R ;

Bissell, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14821-14826

[73] Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo [J].

Wang, Zack Z. ;

Au, Patrick ;

Chen, Tong ;

Shao, Ying ;

Daheron, Laurence M. ;

Bai, Hao ;

Arzigian, Melanie ;

Fukumura, Dai ;

Jain, Rakesh K. ;

Scadden, David T. .

NATURE BIOTECHNOLOGY, 2007, 25 (03) :317-318

[74] Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells [J].

Wartenberg, M ;

Dönmez, F ;

Ling, FC ;

Acker, H ;

Hescheler, J ;

Sauer, H .

FASEB JOURNAL, 2001, 15 (06) :995-1005

[75] Self-organization and branching morphogenesis of primary salivary epithelial cells [J].

Wei, Cindy ;

Larsen, Melinda ;

Hoffman, Matthew P. ;

Yamada, Kenneth M. .

TISSUE ENGINEERING, 2007, 13 (04) :721-735

[76] Biophysical measurement of brain tumor cohesion [J].

Winters, BS ;

Shepard, SR ;

Foty, RA .

INTERNATIONAL JOURNAL OF CANCER, 2005, 114 (03) :371-379

[77] ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix [J].

Wozniak, MA ;

Desai, R ;

Solski, PA ;

Der, CJ ;

Keely, PJ .

JOURNAL OF CELL BIOLOGY, 2003, 163 (03) :583-595

[78] ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo [J].

Wyckoff, Jeffrey B. ;

Pinner, Sophie E. ;

Gschmeissner, Steve ;

Condeelis, John S. ;

Sahai, Erik .

CURRENT BIOLOGY, 2006, 16 (15) :1515-1523

[79] Disabled-2 is an epithelial surface positioning gene [J].

Yang, Dong-Hua ;

Cai, Kathy Q. ;

Roland, Isabelle H. ;

Smith, Elizabeth R. ;

Xu, Xiang-Xi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (17) :13114-13122

[80] Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis [J].

Zaman, Muhammad H. ;

Trapani, Linda M. ;

Siemeski, Alisha ;

MacKellar, Drew ;

Gong, Haiyan ;

Kamm, Roger D. ;

Wells, Alan ;

Lauffenburger, Douglas A. ;

Matsudaira, Paul .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (29) :10889-10894

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