Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala

被引：43

作者：

Morales, M ^{[1
]}

Criado, JR ^{[1
]}

Sanna, PP ^{[1
]}

Henriksen, SJ ^{[1
]}

Bloom, FE ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Neuropharmacol, Alcohol Res Ctr, La Jolla, CA 92037 USA

来源：

BRAIN RESEARCH | 1998年 / 798卷 / 1-2期

关键词：

GAD; interneuron; drug addiction; extended amygdala;

D O I：

10.1016/S0006-8993(98)00457-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The central nucleus of the amygdala (CNA) is a component of the brain reward pathway which is believed to represent an anatomical substrate for drugs of abuse. Previous studies have shown that acute ethanol administration induces the expression of c-fos in the CNA of rat brains. We report here, that over 70% of these c-fos immunoreactive neurons are GABAergic. This observation provides the first anatomical evidence that GABAergic neurons of the CNA are responsive to acute ethanol exposure and suggest that the GABAergic system of the CNA is a key neuronal substrate for ethanol actions on the central nervous system. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：333 / 336

页数：4

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