Biodegradable polymers as biomaterials

During the past two decades significant advances have been made in the development of biodegradable polymeric materials for biomedical applications. Degradable polymeric biomaterials are preferred candidates for developing therapeutic devices such as temporary prostheses, three-dimensional porous structures as scaffolds for tissue engineering and as controlled/sustained release drug delivery vehicles. Each of these applications demands materials with specific physical, chemical, biological, biomechanical and degradation properties to provide efficient therapy. Consequently, a wide range of natural or synthetic polymers capable of undergoing degradation by hydrolytic or enzymatic route are being investigated for biomedical applications. This review summarizes the main advances published over the last 15 years, outlining the synthesis, biodegradability and biomedical applications of biodegradable synthetic and natural polymers. (C) 2007 Elsevier Ltd. All rights reserved.