Complete genome sequence of Treponema pallidum, the syphilis spirochete

被引：807

作者：

Fraser, CM

Norris, SJ

Weinstock, CM

White, O

Sutton, GG

Dodson, R

Gwinn, M

Hickey, EK

Clayton, R

Ketchum, KA

Sodergren, E

Hardham, JM

McLeod, MP

Salzberg, S

Peterson, J

Khalak, H

Richardson, D

Howell, JK

Chidambaram, M

Utterback, T

McDonald, L

Artiach, P

Bowman, C

Cotton, MD

Fujii, C

Garland, S

Hatch, B

Horst, K

Roberts, K

Sandusky, M

Weidman, J

Smith, HO

Venter, JC

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Microbiol & Mol Genet, Houston, TX 77225 USA

[3] Univ Texas, Hlth Sci Ctr, Dept Pathol & Lab Med, Houston, TX 77225 USA

[4] Univ Texas, Hlth Sci Ctr, Ctr Study Emerging & Reemerging Pathogens, Houston, TX 77225 USA

来源：

SCIENCE | 1998年 / 281卷 / 5375期

关键词：

D O I：

10.1126/science.281.5375.375

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phoiphoenolpyruvate: phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.

引用

页码：375 / 388

页数：14

共 86 条

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