Regulation of protective immunity against Leishmania major in mice

被引：74

作者：

Louis, J ^{[1
]}

Himmelrich, H ^{[1
]}

Parra-Lopez, C ^{[1
]}

Tacchini-Cottier, F ^{[1
]}

Launois, P ^{[1
]}

机构：

[1] Univ Lausanne, WHO, Immunol Res & Training Ctr, Inst Biochem, CH-1066 Epalinges, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0952-7915(98)80121-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Resolution of lesions induced by Leishmania major in mice results from the development of Th1 responses. Cytokines produced by Th1 cells activate macrophages to a parasiticidal state. The development of Th2 responses in mice from a few strains underlies susceptibility to infection. Cytokines produced by Th2 cells exacerbate the development of lesions because of their deactivating properties for macrophages. This murine model of infection has provided significant insight into the mechanisms intrinsic to the differentiation of disparate CD4(+) T cell subsets in vivo in animals from different genetic backgrounds.

引用

页码：459 / 464

页数：6

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