Telomerase: regulation, function and transformation

被引:79
作者
Dong, CK
Masutomi, K
Hahn, WC
机构
[1] Brigham & Womens Hosp, Dept Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[3] Broad Inst, Cambridge, MA 02141 USA
关键词
telomere; telomerase; cancer; transformation; senescence;
D O I
10.1016/j.critrevonc.2004.12.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Work from several laboratories over the past decade indicates that the acquisition of constitutive telomerase expression is a critical step during the malignant transformation of human cells. Normal human cells transiently express low levels of telomerase, the ribonucleoprotein responsible for extending and maintaining telomeres, and exhibit telomere shortening after extended passage, whereas most cancers exhibit constitutive telomerase expression and maintain telomeres at stable lengths. These observations establish a direct connection between immortalization and stabilization of telomere structure. However, recent work suggests that telomerase also contributes to cancer development beyond its role in maintaining stable telomere lengths. In this review, we summarize recent observations that support the concept that telomerase plays multiple roles in facilitating human cell transformation. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:85 / 93
页数:9
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