Peptidoglycan recognition proteins: modulators of the microbiome and inflammation

被引：333

作者：

Royet, Julien ^{[1
,2
]}

Gupta, Dipika ^{[3
]}

Dziarski, Roman ^{[3
]}

机构：

[1] CNRS, Inst Biol Dev Marseille Luminy, UMR6216, Marseille, France

[2] Aix Marseille Univ, Marseille, France

[3] Indiana Univ Sch Med NW, Gary, IN 46408 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

GRAM-NEGATIVE BACTERIA; L-ALANINE AMIDASE; DROSOPHILA IMMUNE-RESPONSE; GUT MICROBIOTA; PGRP-LC; STRUCTURAL BASIS; INNATE IMMUNITY; MUTUALIST WIGGLESWORTHIA; INCREASED SUSCEPTIBILITY; MOLECULAR-PATTERNS;

D O I：

10.1038/nri3089

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.

引用

页码：837 / 851

页数：15

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