Concise Review: Stem Cells As an Emerging Platform for Antibody Therapy of Cancer

被引：27

作者：

Frank, Richard T. ^{[1
,3
,4
]}

Najbauer, Joseph ^{[1
]}

Aboody, Karen S. ^{[1
,2
,4
]}

机构：

[1] City Hope Natl Med Ctr, Dept Neurosci, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Div Neurosurg, Duarte, CA 91010 USA

[3] City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA

[4] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA

来源：

STEM CELLS | 2010年 / 28卷 / 11期

关键词：

Antibody; Blood-brain barrier; Cancer therapy; alpha-Carcinoembryonic antigen; CD3; Diabody; EGFR; HER2; Neural stem cells; Mesenchymal stem cells; scFv; CLASS-I; GLIOMA; LYMPHOCYTES; EXPRESSION; SURVIVAL; HYPOXIA;

D O I：

10.1002/stem.513

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may improve antibody therapy of cancer by overcoming these obstacles. STEM CELLS 2010;28:2084-2087

引用

页码：2084 / 2087

页数：4

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