The intriguing world of prothrombin activators from snake venom

被引：96

作者：

Kini, RM ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Sci, Dept Biol Sci, Prot Sci Lab, Singapore 117543, Singapore

来源：

TOXICON | 2005年 / 45卷 / 08期

关键词：

procoagulant proteins; factor Xa; prothrombinase complex; prothrombin activator; anticoagulant; blood clotting; serine protemase;

D O I：

10.1016/j.toxicon.2005.02.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Activation of prothrombin to mature thrombin occurs by the proteolytic action of the prothrombinase complex consisting of a serine proteinase factor Xa, and cofactors factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. They are classified into four groups based on their cofactor requirements. Group A and B prothrombin activators are metalloproteinases whereas group C and D prothrombin activators are serine proteinases. Group C prothrombin activators resemble the mammalian factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of the current knowledge on all prothrombin activators and highlights several intriguing questions that are yet to be answered. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1133 / 1145

页数：13

共 117 条

[1]

ALTIERI DC, 1990, J IMMUNOL, V145, P246

[2] Activation-dependent exposure of the inter-EGF sequence Leu(83)-Leu(88) in factor Xa mediates ligand binding to effector cell protease receptor-1 [J].

Ambrosini, G ;

Plescia, J ;

Chu, KC ;

High, KA ;

Altieri, DC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) :8340-8345

[3]

ATODA H, 1991, J BIOL CHEM, V266, P14903

[4]

BAHNAK BR, 1987, BLOOD, V69, P224

[5] Conantokin-G precursor and its role in γ-carboxylation by a vitamin K-dependent carboxylase from a Conus snail [J].

Bandyopadhyay, PK ;

Colledge, CJ ;

Walker, CS ;

Zhou, LM ;

Hillyard, DR ;

Olivera, BM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5447-5450

[6]

BJOERN S, 1991, J BIOL CHEM, V266, P11051

[7]

Bouchard BA, 1997, J BIOL CHEM, V272, P9244

[8] Human brain pericytes differentially regulate expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood coagulation [J].

Bouchard, BA ;

Shatos, MA ;

Tracy, PB .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) :1-9

[9] Snake venom proteins acting on hemostasis [J].

Braud, S ;

Bon, C ;

Wisner, A .

BIOCHIMIE, 2000, 82 (9-10) :851-859

[10] ACCUMULATION OF SOME SECRETORY ENZYMES IN VENOM GLANDS OF VIPERA-PALAESTINAE [J].

BROWN, RS ;

BROWN, MB ;

BDOLAH, A ;

KOCHVA, E .

AMERICAN JOURNAL OF PHYSIOLOGY, 1975, 229 (06) :1675-1679

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