The intriguing world of prothrombin activators from snake venom

被引：96

作者：

Kini, RM ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Sci, Dept Biol Sci, Prot Sci Lab, Singapore 117543, Singapore

来源：

TOXICON | 2005年 / 45卷 / 08期

关键词：

procoagulant proteins; factor Xa; prothrombinase complex; prothrombin activator; anticoagulant; blood clotting; serine protemase;

D O I：

10.1016/j.toxicon.2005.02.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Activation of prothrombin to mature thrombin occurs by the proteolytic action of the prothrombinase complex consisting of a serine proteinase factor Xa, and cofactors factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. They are classified into four groups based on their cofactor requirements. Group A and B prothrombin activators are metalloproteinases whereas group C and D prothrombin activators are serine proteinases. Group C prothrombin activators resemble the mammalian factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of the current knowledge on all prothrombin activators and highlights several intriguing questions that are yet to be answered. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1133 / 1145

页数：13

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