UV and Near-IR Triggered Release from Polymeric Nanoparticles

被引：306

作者：

Fomina, Nadezda

McFearin, Cathryn

Sermsakdi, Marleen

Edigin, Osayimwense

Almutairi, Adah ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Pharm & Pharmaceut Sci, Dept NanoEngn, La Jolla, CA 92093 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 28期

关键词：

PHOTOLABILE PROTECTING GROUPS; SELF-IMMOLATIVE POLYMERS; CROSS-SECTIONS; DRUG-DELIVERY; NILE RED; DOXORUBICIN; MICELLES;

D O I：

10.1021/ja102595j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model pharmaceutical Nile Red. Triggered burst release of the payload upon irradiation and subsequent degradation of the nanoparticles were observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.

引用

收藏

页码：9540 / 9542

页数：3

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