Infections in patients with inherited defects in phagocytic function

被引：121

作者：

Andrews, T ^{[1
]}

Sullivan, KE ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Div Allergy & Immunol, Philadelphia, PA 19104 USA

来源：

CLINICAL MICROBIOLOGY REVIEWS | 2003年 / 16卷 / 04期

关键词：

D O I：

10.1128/CMR.16.4.597-621.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiolog has also affected patient management by allowing specific, targeted immunomodulatory intervention. The disorders described in this review are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophil and macrophage in infection has benefited not just the patients described in this review but also other patients with similar disease processes.

引用

页码：597 / +

页数：26

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