Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family

被引：104

作者：

Moldenhauer, Jana

Chen, Xiao-Hua

Borriss, Rainer

Piel, Jorn

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[2] Humboldt Univ, Inst Biol, D-10115 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期

关键词：

D O I：

10.1002/anie.200703386

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Molecular traffic jam: The engineering of a bacillaene polyketide synthase deficient in thioesterase (TE) has led to the production of 13 hydrolyzed biosynthetic intermediates (see picture). This unexpected effect provides detailed insights into almost the entire bacillaene pathway and related poorly characterized polyketide routes. © 2007 Wiley-VCH Verlag-GmbH &. Co. KGaA.

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收藏

页码：8195 / 8197

页数：3

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