Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

被引：195

作者：

Bray, PG

Barrett, MP

Ward, SA

de Koning, HP ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Liverpool Liverpool Sch Trop Med, Mol & Biochem Parasitol Grp, Liverpool L3 5QS, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1471-4922(03)00069-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Diamidines, and pentamidine in particular, have a long history as valuable chemotherapeutic agents against infectious disease. Their selectivity is due mostly to selective accumulation by the pathogen, rather than the host cell; and acquired resistance is frequently the result of changes in transmembrane transport of the drug. Here, recent progress in elucidating the mechanisms of diamidine transport in three important protozoan pathogens, Trypanosoma brucei, Leishmania and Plasmodium falciparum, is reviewed, and the implications for drug resistance are discussed.

引用

页码：232 / 239

页数：8

共 70 条

[11] Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum [J].