Presentation of self and microbial lipids by CD1 molecules

被引：54

作者：

Matsuda, JL

Kronenberg, M

机构：

[1] Univ Calif San Diego, Dept Biol, San Diego, CA 92121 USA

[2] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(00)00176-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD1 molecules present both self lipids and microbial lipids. Recent studies have elucidated novel antigenic structures that can be presented by CD1 for T cell stimulation, as well as new pathways for lipid-antigen presentation. Additionally, the development of lipid-CD1 tetramers now permits the tracking of CD1-reactive T cells during immune responses. Despite this, the roles of CD1-reactive T cells in both host defense and immune regulation remain to be unequivocally defined.

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页码：19 / 25

页数：7

相关论文

共 61 条

[1] Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls [J].

Apostolou, I ;

Takahama, Y ;

Belmant, C ;

Kawano, T ;

Huerre, M ;

Marchal, G ;

Cui, J ;

Taniguchi, M ;

Nakauchi, H ;

Fournié, JJ ;

Kourilsky, P ;

Gachelin, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5141-5146

[2] RECOGNITION OF A LIPID ANTIGEN BY CD1-RESTRICTED ALPHA-BETA(+) T-CELLS [J].

BEEKMAN, EM ;

PORCELLI, SA ;

MORITA, CT ;

BEHAR, SM ;

FURLONG, ST ;

BRENNER, MB .

NATURE, 1994, 372 (6507) :691-694

[3] Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis [J].

Behar, SM ;

Dascher, CC ;

Grusby, MJ ;

Wang, CR ;

Brenner, MB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (12) :1973-1980

[4] Mouse CD1-specific NK1 T cells: Development, specificity, and function [J].

Bendelac, A ;

Rivera, MN ;

Park, SH ;

Roark, JH .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :535-562

[5] In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers [J].

Benlagha, K ;

Weiss, A ;

Beavis, A ;

Teyton, L ;

Bendelac, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (11) :1895-1903

[6] Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens [J].

Briken, V ;

Jackman, RM ;

Watts, GFM ;

Rogers, RA ;

Porcelli, SA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :281-287

[7] Highly conserved antigen-presenting function of CD1d molecules [J].

Brossay, L ;

Kronenberg, M .

IMMUNOGENETICS, 1999, 50 (3-4) :146-151

[8] CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution [J].

Brossay, L ;

Chioda, M ;

Burdin, N ;

Koezuka, Y ;

Casorati, G ;

Dellabona, P ;

Kronenberg, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1521-1528

[9]

Brossay L, 1998, J IMMUNOL, V160, P3681

[10] Structural requirements for antigen presentation by mouse CD1 [J].

Burdin, N ;

Brossay, L ;

Degano, M ;

Iijima, H ;

Gui, M ;

Wilson, IA ;

Kronenberg, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10156-10161

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