Presentation of self and microbial lipids by CD1 molecules

被引：54

作者：

Matsuda, JL

Kronenberg, M

机构：

[1] Univ Calif San Diego, Dept Biol, San Diego, CA 92121 USA

[2] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(00)00176-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD1 molecules present both self lipids and microbial lipids. Recent studies have elucidated novel antigenic structures that can be presented by CD1 for T cell stimulation, as well as new pathways for lipid-antigen presentation. Additionally, the development of lipid-CD1 tetramers now permits the tracking of CD1-reactive T cells during immune responses. Despite this, the roles of CD1-reactive T cells in both host defense and immune regulation remain to be unequivocally defined.

引用

页码：19 / 25

页数：7

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