Multisensory cortical signal increases and decreases during vestibular galvanic stimulation (fMRI)

被引:340
作者
Bense, S
Stephan, T
Yousry, TA
Brandt, T
Dieterich, M
机构
[1] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany
[2] Univ Munich, Klinikum Grosshadern, Dept Neuroradiol, D-81377 Munich, Germany
关键词
D O I
10.1152/jn.2001.85.2.886
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Functional magnetic resonance imaging blood-oxygenation-level-dependent (BOLD) signal increases (activations) and BOLD signal decreases ("deactivations") were compared in six healthy volunteers during galvanic vestibular (mastoid) and galvanic cutaneous (neck) stimulation in order to differentiate vestibular from ocular motor and nociceptive functions. By calculating the contrast for vestibular activation minus cutaneous activation for the group, we found activations in the anterior parts of the insula, the paramedian and dorsolateral thalamus, the putamen, the inferior parietal lobule [Brodmann area (BA) 40], the precentral gyrus (frontal eye field, BA 6), the middle frontal gyrus (prefrontal cortex, BA 46/9), the middle temporal gyrus (BA 37), the superior temporal gyrus (BA 22), and the anterior cingulate gyrus (BA 32) as well as in both cerebellar hemispheres. These activations can be attributed to multisensory vestibular and ocular motor functions. Single-subject analysis in addition showed distinctly nonoverlapping activations in the posterior insula, which corresponds to the parieto-insular vestibular cortex in the monkey. During vestibular stimulation, there was also a significant signal decrease in the visual cortex (BA 18, 19), which spared BA 17. A different "deactivation" was found during cutaneous stimulation; it included upper parieto-occipital areas in the middle temporal and occipital gyri (BA 19/39/18). Under both stimulation conditions, there were signal decreases in the somatosensory cortex (BA 2/3/4). Stimulus-dependent, inhibitory vestibular-visual, and nociceptive-somatosensory interactions may be functionally significant for processing perception and sensorimotor control.
引用
收藏
页码:886 / 899
页数:14
相关论文
共 96 条
  • [31] DIETERICH M, 1999, NEUROIMAGE, V6, P499
  • [32] DIETERICH M, IN PRESS NEUROLOGY
  • [33] Cooling-specific spinothalamic neurons in the monkey
    Dostrovsky, JO
    Craig, AD
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (06) : 3656 - 3665
  • [34] RESPONSE PROPERTIES AND RECEPTIVE FIELDS OF CELLS IN AN ANATOMICALLY DEFINED REGION OF SUPERIOR TEMPORAL SULCUS IN MONKEY
    DUBNER, R
    ZEKI, SM
    [J]. BRAIN RESEARCH, 1971, 35 (02) : 528 - &
  • [35] MANY AREAS IN THE HUMAN BRAIN RESPOND TO VISUAL-MOTION
    DUPONT, P
    ORBAN, GA
    DEBRUYN, B
    VERBRUGGEN, A
    MORTELMANS, L
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (03) : 1420 - 1424
  • [36] ANATOMIC CONNECTIONS OF INFERIOR PARIETAL CORTEX (AREA-7) WITH SUBCORTICAL STRUCTURES RELATED TO VESTIBULO-OCULAR FUNCTION IN A MONKEY (MACACA-FASCICULARIS)
    FAUGIER-GRIMAUD, S
    VENTRE, J
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1989, 280 (01) : 1 - 14
  • [37] MRI of functional deactivation:: Temporal and spatial characteristics of oxygenation-sensitive responses in human visual cortex
    Fransson, P
    Krüger, G
    Merboldt, KD
    Frahm, J
    [J]. NEUROIMAGE, 1999, 9 (06) : 611 - 618
  • [38] Friston K., 1995, HUMAN BRAIN MAPPING, V2, P189, DOI [DOI 10.1002/HBM.460020402, 10.1002/hbm.460020402]
  • [39] Friston K., 1995, HUM BRAIN MAP, V2, P165, DOI DOI 10.1002/HBM.460030303
  • [40] Intracortical microstimulation of bilateral frontal eye field
    Fujii, N
    Mushiake, H
    Tanji, J
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1998, 79 (04) : 2240 - 2244