Misinterpretation in Nanotoxicology: A Personal Perspective

被引：38

作者：

Alkilany, Alaaldin M. ^{[1
]}

Mahmoud, Nouf N. ^{[1
]}

Hashemi, Fatemeh ^{[2
]}

Hajipour, Mohammad J. ^{[4
]}

Farvadi, Fakhrosadat ^{[2
]}

Mahmoudi, Morteza ^{[2
,3
]}

机构：

[1] Univ Jordan, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Amman 11942, Jordan

[2] Univ Tehran Med Sci, Fac Pharm, Dept Nanotechnol, Tehran, Iran

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesiol, Boston, MA 02115 USA

[4] Bushehr Univ Med Sci, Persian Gulf Biomed Sci Res Inst, Persian Gulf Marine Biotechnol Res Ctr, Bushehr, Iran

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2016年 / 29卷 / 06期

关键词：

PROTEIN CORONA INFLUENCES; GOLD NANOPARTICLES; CELLULAR UPTAKE; INTERSTITIAL PRESSURE; BIOLOGICAL IDENTITY; TOXICITY; ADSORPTION; SURFACE; CELLS; INTERNALIZATION;

D O I：

10.1021/acs.chemrestox.6b00108

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

As an emerging field, nanotoxicology is gaining significant interest from scientists as well as from international regulatory firms in an attempt to build accumulated knowledge on this topic, which will be the basis for regulatory codes and safer nanotechnology. However, conflicting results and findings are abundant in the literature calling for more careful experimental design, result interpretation, and detailed reporting. In this perspective, we focus on misinterpretation in nanotoxicology and highlight the importance of proper experimental practice to avoid artifacts by discussing various examples from the literature.

引用

页码：943 / 948

页数：6

共 49 条

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Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles [J].