The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat

被引：64

作者：

Govoni, S

Masoero, E

Favalli, L

Rozza, A

Scelsi, R

Viappiani, S

Buccellati, C

Sala, A

Folco, G

机构：

[1] Univ Pavia, Dept Appl & Expt Pharmacol, I-27100 Pavia, Italy

[2] Univ Pavia, Dept Human Pathol, I-27100 Pavia, Italy

[3] Univ Milan, Inst Pharmacol Sci, I-20133 Milan, Italy

来源：

NEUROSCIENCE LETTERS | 2001年 / 303卷 / 02期

关键词：

neuroprotection; cerebral ischemia; cyclooxygenase; prostaglandin endoperoxide synthase; rats;

D O I：

10.1016/S0304-3940(01)01675-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Focal ischemia was induced in the fronto-parietal region of rat brain, by injection of Rose Bengal, followed by light activation. Focal ischemia was accompanied by formation of PGD(2) peaking 60-90 min post irradiation and declining thereafter. Increased Cycloxygenase-2 (COX-2) expression was also observed. Control ischemic rats showed distinct morphological alterations with necrosis of neurons, glial cells and blood vessels, surrounded by a halo with pyknotic cells with cytoplasm swelling and vacuolization. Compound SC58236, a selective COX-2 inhibitor, dose-dependently prevented, ischemia-induced eicosanoid formation (area under the curve (AUC) of controls: 3.11 +/- 0.87; AUC of 20 mg/kg SC58236: 0.39 +/- 0.24), and caused significant reduction of damaged area (30.7 and 18.9% at SC58236 20 and 6.6 mg/kg), suggesting that selective inhibitors of COX-2 are neuroprotective. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：91 / 94

页数：4

共 18 条

[1] Prostaglandins stimulate calcium-dependent glutamate release in astrocytes [J].