Biogenesis and function of extracellular vesicles in cancer

被引：756

作者：

Bebelman, Maarten P. ^{[1
,2
]}

Smit, Martine J. ^{[2
]}

Pegtel, D. Michiel ^{[1
]}

Baglio, S. Rubina ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pathol, Canc Ctr Amsterdam, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Div Med Chem, Amsterdam Inst Mol Med & Syst, Amsterdam, Netherlands

来源：

PHARMACOLOGY & THERAPEUTICS | 2018年 / 188卷

基金：

欧盟地平线“2020”;

关键词：

Extracellular vesicles; Exosome biogenesis; Cargo sorting; Tumor microenvironment; Tumor-stroma communication; TUMOR-DERIVED MICROVESICLES; METASTATIC NICHE FORMATION; DOUBLE-STRANDED DNA; EXOSOME SECRETION; LYSOSOMAL DEGRADATION; MULTIVESICULAR BODIES; MEMBRANE-SCISSION; PLASMA-MEMBRANE; CELL MOTILITY; HUMAN BREAST;

D O I：

10.1016/j.pharmthera.2018.02.013

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell "state" and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior. (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：1 / 11

页数：11

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