The diversity of globin-coupled sensors

被引:55
作者
Freitas, TAK
Hou, SB
Alam, M
机构
[1] Univ Hawaii, Dept Microbiol, Honolulu, HI 96822 USA
[2] Maui High Performance Comp Ctr, Maui, HI 96753 USA
关键词
globin; archaeon; heme-based sensor; globin-coupled sensor; GLUTATHIONE-S-TRANSFERASE; OXYGEN SENSOR; HEME-PROTEIN; ACETOBACTER-XYLINUM; CELLULOSE SYNTHESIS; ESCHERICHIA-COLI; KINASE-ACTIVITY; DI-GMP; EXPRESSION; INDUCTION;
D O I
10.1016/S0014-5793(03)00923-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recently discovered globin-coupled sensors (GCSs) are heme-containing two-domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi-domain C-terminal transmitters through a search of the complete and incomplete microbial genome datasets. The GCS superfamily is composed of two major subfamilies: the aerotactic and gene regulators. We postulate the existence of protoglobin in Archaea as the predecessor to the chimeric GCS. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
引用
收藏
页码:99 / 104
页数:6
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