Recent advances in heme-protein sensors

被引：97

作者：

Chan, MK

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(00)00193-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, an increasing number of proteins have been discovered which utilize heme cofactors to sense oxygen, carbon monoxide and nitric oxide. The identification and characterization of these proteins are revising our understanding of heme-mediated allostery first established in the early 1960s. Biochemical and structural studies are revealing new mechanisms for heme-driven conformational changes distinct from the classical hemoglobin model.

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页码：216 / 222

页数：7

相关论文

共 35 条

[1] Single transduction in the transcriptional activator CooA containing a heme-based CO sensor: Isolation of a dominant positive mutant which is active as the transcriptional activator even in the absence of CO [J].

Aono, S ;

Matsuo, T ;

Shimono, T ;

Ohkubo, K ;

Takasaki, H ;

Nakajima, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 240 (03) :783-786

[2] Redox-controlled ligand exchange of the heme in the CO-sensing transcriptional activator CooA [J].

Aono, S ;

Ohkubo, K ;

Matsuo, T ;

Nakajima, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) :25757-25764

[3] Transcriptional regulation of gene expression by metalloproteins [J].

Aono, S ;

Nakajima, H .

PROGRESS IN REACTION KINETICS AND MECHANISM, 2000, 25 (01) :65-107

[4] Structure and function of CooA, a novel transcriptional regulator containing a b-type heme as a CO sensor [J].

Aono, S ;

Nakajima, H .

COORDINATION CHEMISTRY REVIEWS, 1999, 190 :267-282

[5] CooA, CAP and allostery [J].

Chan, MK .

NATURE STRUCTURAL BIOLOGY, 2000, 7 (10) :822-824

[6]

Chan MK, 2000, J PORPHYR PHTHALOCYA, V4, P358, DOI 10.1002/(SICI)1099-1409(200006/07)4:4<358::AID-JPP243>3.0.CO

[7]

2-A

[8] X-RAY CRYSTAL-STRUCTURE OF FERRIC APLYSIA-LIMACINA MYOGLOBIN IN DIFFERENT LIGANDED STATES [J].

CONTI, E ;

MOSER, C ;

RIZZI, M ;

MATTEVI, A ;

LIONETTI, C ;

CODA, A ;

ASCENZI, P ;

BRUNORI, M ;

BOLOGNESI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 233 (03) :498-508

[9] Dos, a heme-binding PAS protein from Escherichia coli, is a direct oxygen sensor [J].

Delgado-Nixon, VM ;

Gonzalez, G ;

Gilles-Gonzalez, MA .

BIOCHEMISTRY, 2000, 39 (10) :2685-2691

[10] Guanylate cyclase and the .NO/cGMP signaling pathway [J].

Denninger, JW ;

Marletta, MA .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1411 (2-3) :334-350

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