SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption

被引：71

作者：

McCormick, JA ^{[1
]}

Bhalla, V

Pao, AC

Pearce, D

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00053.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

引用

页码：134 / 139

页数：6

共 42 条

[1] Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome [J].

Abriel, H ;

Loffing, J ;

Rebhun, JF ;

Pratt, JH ;

Schild, L ;

Horisberger, JD ;

Rotin, D ;

Staub, O .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (05) :667-673

[2] Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance [J].

Asher, C ;

Sinha, I ;

Garty, H .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1612 (01) :59-64

[3] The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action [J].

Bhargava, A ;

Fullerton, MJ ;

Myles, K ;

Purdy, TM ;

Funder, JW ;

Pearce, D ;

Cole, TJ .

ENDOCRINOLOGY, 2001, 142 (04) :1587-1594

[4] Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure [J].

Busjahn, A ;

Aydin, A ;

Uhlmann, R ;

Krasko, C ;

Bähring, S ;

Szelestei, T ;

Feng, YX ;

Dahm, S ;

Sharma, AM ;

Luft, FC ;

Lang, F .

HYPERTENSION, 2002, 40 (03) :256-260

[5] Epithelial sodium channel regulated by aldosterone-induced protein sgk [J].

Chen, SY ;

Bhargava, A ;

Mastroberardino, L ;

Meijer, OC ;

Wang, J ;

Buse, P ;

Firestone, GL ;

Verrey, F ;

Pearce, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2514-2519

[6] Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene [J].

Chen, WS ;

Xu, PZ ;

Gottlob, K ;

Chen, ML ;

Sokol, K ;

Shiyanova, T ;

Roninson, I ;

Weng, W ;

Suzuki, R ;

Tobe, K ;

Kadowaki, T ;

Hay, N .

GENES & DEVELOPMENT, 2001, 15 (17) :2203-2208

[7] In vitro phosphorylation of COOH termini of the epithelial Na+ channel and its effects on channel activity in Xenopus oocytes [J].

Chigaev, A ;

Lu, G ;

Shi, HK ;

Asher, C ;

Xu, R ;

Latter, H ;

Seger, R ;

Garty, H ;

Reuveny, E .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 280 (06) :F1030-F1036

[8] Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice [J].

Cho, H ;

Thorvaldsen, JL ;

Chu, QW ;

Feng, F ;

Birnbaum, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38349-38352

[9] Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) [J].

Cho, H ;

Mu, J ;

Kim, JK ;

Thorvaldsen, JL ;

Chu, QW ;

Crenshaw, EB ;

Kaestner, KH ;

Bartolomei, MS ;

Shulman, GI ;

Birnbaum, MJ .

SCIENCE, 2001, 292 (5522) :1728-1731

[10] Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1 [J].

Dai, FY ;

Yu, L ;

He, H ;

Zhao, Y ;

Yang, J ;

Zhang, XN ;

Zhao, SY .

GENOMICS, 1999, 62 (01) :95-97

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