SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption

被引：71

作者：

McCormick, JA ^{[1
]}

Bhalla, V

Pao, AC

Pearce, D

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00053.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

引用

页码：134 / 139

页数：6

共 42 条

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JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (25) :23066-23075

[42] The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1 [J].

Yun, CC ;

Palmada, M ;

Embark, HM ;

Fedorenko, O ;

Feng, YX ;

Henke, G ;

Setiawan, I ;

Boehmer, C ;

Weinman, EJ ;

Sandrasagra, S ;

Korbmacher, C ;

Cohen, P ;

Pearce, D ;

Lang, F .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 (12) :2823-2830

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