Antileishmanial activity of compounds extracted and characterized from Centrolobium sclerophyllum

被引：70

作者：

Araujo, CAC

Alegrio, LV

Leon, LL ^{[1
]}

机构：

[1] Inst Oswaldo Cruz, Dept Imunol, BR-21045900 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Dept Quim, Rio De Janeiro, Brazil

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 03期

关键词：

Centrolobium sclerophyllum; Leguminosae; diarylheptanoids; isoflavonoid; Leishmania amazonensis; promastigotes; antileishmanial activity;

D O I：

10.1016/S0031-9422(97)00976-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drugs derived from plants, which had not been tested up to now in trypanosomatids, were studied. The compounds extracted from Centrolobium sclerophyllum, Leguminosae, were two diarylheptanoids, 2[beta-(p-hydroxyphenyl)-ethyl]6(p-hydroxyphenyl)-tetrahydropyran)-ethyl]-6Ca-hydroxyphenyl and 3-hydroxy-1,7-bis-(4',4"-dibydroxyphenyl)-heptane, and one isoflavonoid, 7,3'-dihydroxy-4'-methoxy-isoflavone. Extracellular forms (promastigotes) of Leishmania amazonensis were assayed in presence of these compounds and the results showed that both diarylheptanoids and the isoflavonoid had a good antileishmanial activity with the LD50 = 77 nM, LD50 = 86nM and LD50 = 140nM, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：751 / 754

页数：4

共 23 条

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