Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

被引：303

作者：

Gao, Wei ^{[1
,2
,3
]}

Nyein, Hnin Y. Y. ^{[1
,2
,3
]}

Shahpar, Ziba ^{[1
,2
]}

Fahad, Hossain M. ^{[1
,2
]}

Chen, Kevin ^{[1
,2
,3
]}

Emaminejad, Sam ^{[1
,2
,3
]}

Gao, Yuji ^{[1
,2
,3
]}

Tai, Li-Chia ^{[1
,2
,3
]}

Ota, Hiroki ^{[1
,2
,3
]}

Wu, Eric ^{[1
,2
]}

Bullock, James ^{[1
,2
,3
]}

Zeng, Yuping ^{[1
]}

Lien, Der-Hsien ^{[1
,2
,3
]}

Javey, Ali ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Berkeley Sensor & Actuator Ctr, Berkeley, CA 94720 USA

[3] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

来源：

ACS SENSORS | 2016年 / 1卷 / 07期

基金：

日本学术振兴会;

关键词：

flexible electronics; wearable biosensors; heavy metals monitoring; sweat; multiplexed sensing; temperature compensation; ANODIC-STRIPPING VOLTAMMETRY; HUMAN SWEAT; ELECTRONIC SKIN; ELECTROCHEMICAL SENSOR; TRACE-METALS; COPPER; MICROELECTRODE; SPECTROMETRY; PERSPIRATION; EXCRETION;

D O I：

10.1021/acssensors.6b00287

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual's health state such as heavy metal exposure and aid the related clinical investigations.

引用

页码：866 / 874

页数：9

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