Worsening of delusional depression after sleep deprivation: case reports

被引：18

作者：

Benedetti, F ^{[1
]}

Zanardi, R ^{[1
]}

Colombo, C ^{[1
]}

Smeraldi, E ^{[1
]}

机构：

[1] Univ Milan, Sch Med, Dept Neuropsychiat Sci, Osped San Raffaele,Ist Sci, I-20127 Milan, Italy

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1999年 / 33卷 / 01期

关键词：

psychotic depression; sleep deprivation; serotonin; dopamine;

D O I：

10.1016/S0022-3956(98)00053-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Five patients (three bipolars and two unipolars) affected by a major depressive episode with psychotic features were treated with total sleep deprivation (TSD) without concurrent psychotropic medication. After TSD we observed a worsening in psychotic as well as in depressive symptoms as rated on the Dimension of Delusional Experience Rating Scale and on Hamilton Rating Scale for Depression, respectively. TSD is known to markedly enhance the activity of brain monoaminergic pathways. Given the;interaction between brain serotonergic and dopaminergic systems in delusional depression, it is possible that an enhancement in dopaminergic activity may be responsible of the symptomatological worsening in delusional depressives observed after TSD. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：69 / 72

页数：4

共 32 条

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