A novel method with improved power to detect recombination hotspots from polymorphism data reveals multiple hotspots in human genes

被引:39
作者
Fearnhead, P [1 ]
Smith, NGC [1 ]
机构
[1] Univ Lancaster, Dept Math & Stat, Fylde Coll, Lancaster LA1 4YF, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1086/497579
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We introduce a new method for detection of recombination hotspots from population genetic data. This method is based on (a) defining an (approximate) penalized likelihood for how recombination rate varies with physical position and (b) maximizing this penalized likelihood over possible sets of recombination hotspots. Simulation results suggest that this is a more powerful method for detection of hotspots than are existing methods. We apply the method to data from 89 genes sequenced in African American and European American populations. We find many genes with multiple hotspots, and some hotspots show evidence of being population-specific. Our results suggest that hotspots are randomly positioned within genes and could be as frequent as one per 30 kb.
引用
收藏
页码:781 / 794
页数:14
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