Functional acrylic acid as stabilizer for synthesis of smart hydrogel particles containing a magnetic Fe3O4 core

被引：40

作者：

Chou, Feng-Yi ^{[1
]}

Shih, Chao-Ming ^{[1
]}

Tsai, Meng-Chao ^{[1
]}

Chiu, Wen-Yen ^{[2
]}

Lue, Shingjiang Jessie ^{[1
]}

机构：

[1] Chang Gang Univ, Dept Chem & Mat Engn, Tao Yuan 333, Taiwan

[2] Natl Taiwan Univ, Dept Chem Engn, Taipei 106, Taiwan

来源：

POLYMER | 2012年 / 53卷 / 14期

关键词：

Magnetite (Fe3O4); N-Isopropylacrylamide; Core-shell structure; POLY(N-ISOPROPYLACRYLAMIDE-CO-ACRYLIC ACID); RESPONSIVE HYDROGELS; NANOPARTICLES; MICROSPHERES; THERAPY; RELEASE; ROUTE;

D O I：

10.1016/j.polymer.2012.05.010

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

This paper reports a novel method to synthesize magnetic, stimuli-sensitive latex nanoparticles made with magnetite/poly(N-isopropylacrylamide-co-acrylic acid) (Fe3O4/P(NIPAAm-co-AAc)). To form a stabilized suspended core, iron oxide (Fe3O4) was functionalized with AAc such that further polymerization with NIPAAm and AAc monomers could occur. The P(NIPAAm-co-AAc) shell layer exhibited thermosensitive properties. The inclusion of Fe3O4 into the latex nanoparticles was confirmed using transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, thermogravimetric analyzer (TGA), and superconducting quantum interference device magnetometer. The NIP-(AAc2.6-Fe) latex nanoparticles contained 2.25% Fe3O4 (by weight), as determined by TGA analysis. The particle diameters measured approximately 160-240 nm with a lower critical solution temperature of 35 degrees C. These novel magnetic stimuli-responsive latex nanoparticles have potential applications in numerous fields, such as catalyst supports, protein immobilization, cancer therapy, target drug delivery systems, and other biomedical applications. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2839 / 2846

页数：8

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