The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II

被引：29

作者：

Díez, E ^{[1
]}

Dixon, DJ ^{[1
]}

Ley, SV ^{[1
]}

Polara, A ^{[1
]}

Rodríguez, F ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

HELVETICA CHIMICA ACTA | 2003年 / 86卷 / 11期

关键词：

D O I：

10.1002/hlca.200390314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of phytotoxic nonenolide herbarumin 11 (1) has been achieved by implementation of butane diacetal (BDA)-desymmetrised glycolate building blocks. Three of the four stereogenic centres present in the key coupling fragments were generated from both enantiomeric forms of the BDA building block in highly diastereoselective alkylation and aldol reactions.

引用

页码：3717 / 3729

页数：13

共 52 条

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