Genetic manipulation of the renin-angiotensin system

被引：20

作者：

Doan, TN ^{[1
]}

Gletsu, N ^{[1
]}

Cole, J ^{[1
]}

Bernstein, KE ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 04期

关键词：

D O I：

10.1097/00041552-200107000-00002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin system is widely known for its importance in control of blood pressure, electrolyte homeostasis and volume regulation, Recently, renin-angiotensin system function was studied using homologous recombination in embryonic stem cells to manipulate the mouse genome. Angiotensinogen, angiotensin-converting enzyme and angiotensin II receptors were each eliminated in separate lines of mice, These null animals share similar phenotypes, such as a lowering of blood pressure, abnormal renal development, malfunction of the kidney and, unexpectedly, a decrease in hematocrit. In addition, angiotensin-converting enzyme null male mice sire far smaller litters than male wild-type mice. This suggests an unexplored role for angiotensin-converting enzyme in conception. Future studies with these and other genetically engineered mice lines will reveal novel physiological effects of angiotensin II. Curr Opin Nephrol Hypertens 10:483-491. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：483 / 491

页数：9

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