Asymmetric Dimethylarginine: a Novel Cardiovascular Risk Factor in End-stage Renal Disease

被引：13

作者：

Alsagaff, M. Yusuf ^{[1
,3
]}

Thaha, M. ^{[2
]}

Aminuddin, M. ^{[1
]}

Yogiantoro, R. M. ^{[1
]}

Yogiantoro, M. ^{[2
]}

Tomino, Y. ^{[3
]}

机构：

[1] Airlangga Univ, Dept Cardiol & Vasc Med, Sch Med, Surabaya 60118, Indonesia

[2] Airlangga Univ, Nephrol Hypertens Div, Sch Med, Surabaya 60118, Indonesia

[3] Juntendo Univ, Div Nephrol, Dept Internal Med, Fac Med, Tokyo, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2012年 / 40卷 / 01期

关键词：

END-STAGE RENAL DISEASE; ARTERIOSCLEROSIS; CAROTID INTIMA-MEDIA THICKNESS; ASYMMETRIC DIMETHYLARGININE (ADMA); INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; INTRAVENOUS N-ACETYLCYSTEINE; CAROTID-ARTERY; ENDOTHELIAL DYSFUNCTION; PLASMA-CONCENTRATION; DIABETIC-PATIENTS; OXIDATIVE STRESS; HEMODIALYSIS; ATHEROSCLEROSIS;

D O I：

10.1177/147323001204000135

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

OBJECTIVE: This cross-sectional study explored the association between carotid intima-media thickness (CIMT) and the oxidative stress markers asymmetric dimethylarginine (ADMA) and homocysteine in patients with end-stage renal disease who were on haemodialysis. METHODS: A total of 30 patients undergoing chronic haemodialysis treatment were recruited to this study. Homocysteine and ADMA levels were determined using a fluorescence polarization immunoassay and an enzyme-linked immunosorbent assay, respectively. CIMT was measured as a marker of atherosclerosis using high-resolution ultrasonography and was performed after haemodialysis. RESULTS: Significant positive correlations were found between CIMT and ADMA, and CIMT and duration of haemodialysis. Linear regression analysis showed that ADMA level and age were significant independent determinants of CIMT, whereas homocysteine was not. CONCLUSIONS: The relationship demonstrated between plasma ADMA and carotid artery thickening suggests that ADMA may be a novel marker of atherosclerosis in patients on haemodialysis.

引用

页码：340 / 349

页数：10

共 64 条

[1] SYSTEMIC NATURE OF ENDOTHELIAL DYSFUNCTION IN ATHEROSCLEROSIS [J].