Recent developments in molecular action of antihormones

被引:14
作者
Fuhrmann, U
Parczyk, K
Klotzbücher, M
Klocker, H
Cato, ACB
机构
[1] Forschungszentrum Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany
[2] Schering AG, Res Labs, D-13342 Berlin, Germany
[3] Univ Innsbruck, Dept Urol, A-6020 Innsbruck, Austria
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 1998年 / 76卷 / 07期
关键词
antiprogesterone; antiestrogen; antiandrogen; mutant receptors; antihormone withdrawal syndrome;
D O I
10.1007/s001090050245
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Antihormones are by definition antagonists of steroid hormone action. They interact with the ligand binding domains of steroid hormone receptors and competitively inhibit the action of the receptors by mechanisms that are not quite understood. In certain cases antihormones also exhibit agonistic activity especially in connection with certain naturally occurring receptor mutants. These observations together with findings of indiscriminate interaction of antihormones with several classes of steroid receptors have necessitated a search of more effective and reliable antihormones. Recent advances in the resolution of the crystal structure of the ligand binding domains of certain members of the steroid receptor family and identification of non-liganded activation of steroid receptors have produced considerable information that can be harnessed into a fruitful search for a new generation of antihormones.
引用
收藏
页码:512 / 524
页数:13
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