Inhibitors of β-amyloid-induced toxicity by modulating the Akt signaling pathway

被引：22

作者：

Nakagami, Y ^{[1
]}

机构：

[1] Sankyo Co Ltd, Biol Res Lab, Shinagawa Ku, Tokyo 1408710, Japan

来源：

DRUG NEWS & PERSPECTIVES | 2004年 / 17卷 / 10期

关键词：

D O I：

10.1358/dnp.2004.17.10.873917

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Akt signaling pathway plays a crucial role in neuronal survival, leading to inhibition of apoptosis. Many stimulants including neurotrophins are reported to activate this pathway in preclinical studies; however, there are no drugs for neurodegenerative diseases adopting such a concept on the market so far. Among neurodegenerative diseases, Alzheimer's disease is the most common and characterized by senile plaques and neurofibrillary tangles, which consist of beta-amyloid and hyperphosphorylated tau, respectively. Recent studies suggest that activation of Akt inhibits toxicity of beta-amyloid and formation of neurofibrillary tangles, leading to protection of neurons against apoptosis. This review discusses the possibility of treatment of Alzheimer's disease by activating the Akt signaling pathway. (c) 2004 Prous Science. All rights reserved.

引用

页码：655 / 660

页数：6

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