A case of aortic valve disease associated with Tropheryma whippelii infection in the absence of other signs of Whipple's disease

被引：25

作者：

Geissdörfer, W

Wittmann, I

Seitz, G

Cesnjevar, R

Röllinghoff, M

Schoerner, C

Bogdan, C

机构：

[1] Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany

[2] Bamberg Clin, Inst Pathol, D-96049 Bamberg, Germany

[3] Univ Erlangen Nurnberg, Ctr Cardiac Surg, D-91054 Erlangen, Germany

来源：

INFECTION | 2001年 / 29卷 / 01期

关键词：

Tropheryma whippelii; Whipple's disease; endocarditis; PCR;

D O I：

10.1007/s15010-001-0135-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A case of endocarditis caused by Tropheryma whippelii is reported. The 69-year-old patient was diagnosed as suffering from severe aortic regurgitation requiring aortic valve replacement, but showed no other symptoms of Whipple's disease, T. whippelii was detected in the explanted aortic valve by broad-range PCR amplification of the 165 rDNA and subsequent sequence analysis of the product. The etiologic agent was classified as a type 2A sequence variant based on the 16S-235 intergenic spacer and the 23S rDNA (domain III) sequences. The histological examination of the aortic valve was compatible with Whipple's disease. A duodenal biopsy revealed an infection with Giardia lamblia, but T. whippelii and histological signs of Whipple's disease were not detectable.

引用

页码：44 / 47

页数：4

共 22 条

[11] Reassessment of the phylogenetic position of the bacterium associated with Whipple's disease and determination of the 16S-23S ribosomal intergenic spacer sequence [J].