Melatonin reduces interleukin secretion in amyloid-β stressed mouse brain slices

被引：28

作者：

Clapp-Lilly, KL

Smith, MA

Perry, G

Duffy, LK ^{[1
]}

机构：

[1] Univ Alaska Fairbanks, Inst Arctic Biol, Dept Chem & Biochem, Fairbanks, AK 99775 USA

[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2001年 / 134卷 / 01期

关键词：

Alzheimers disease; amyloid; melatonin; interleukins; organotypic culture;

D O I：

10.1016/S0009-2797(00)00319-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurodegeneration in Alzheimer's disease (AD) is associated with many features of the immune system. For example, cytokines such as IL-6, synthesized by microglia and astrocytes, are associated with senile plaques. To further study the role of cytokines in early stage AD neurodegeneration, an organotypic mouse brain slice culture system with microglia and astrocytes was developed. Amyloid-beta (A beta1-40) induced the secretion of both IL-1 beta and IL-6. Melatonin, an antioxidant and pineal hormone, reduced interleukin secretion in a concentration dependent manner. We also observed that melatonin, alone, had no effect on IL-1 beta secretion but at a concentration of 500 muM induced the secretion of IL-6. This organotypic slice system can be used to study the early role of immune system molecules on neurodegeneration (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：101 / 107

页数：7

共 24 条

[1]

AISEN PS, 1994, AM J PSYCHIAT, V151, P1105

[2] VITAMIN-E PROTECTS NERVE-CELLS FROM AMYLOID BETA-PROTEIN TOXICITY [J].