Label-free biosensor using an optical waveguide with induced Bragg grating of variable strength

被引:5
作者
Dotsenko, AV
Diikov, AL
Vartanyan, TA
机构
[1] Corning Sci Ctr Modeling & Simulat, St Petersburg 199034, Russia
[2] State Opt Inst, St Petersburg 199034, Russia
关键词
biological sensor; integrated optics; waveguide; Bragg reflector;
D O I
10.1016/S0925-4005(03)00319-8
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A new design of a highly sensitive optical biosensor is described. It consists of a planar waveguide with a corrugated surface, tuned to be a resonant Bragg reflector. Only the heights of the corrugation are covered by an opto-chemical transducer layer that selectively adsorbs target biomolecules. Upon adsorption, the corrugation depth rises and reflection coefficient changes. This is used to monitor surface reactions. Theoretical analysis and mathematical modeling proves that the device sensitivity compares favorably with current known designs. The proposed biosensor is shown to possess a unique capability of unambiguous discrimination between surface reactions and refraction index changes in the bulk solution. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:116 / 121
页数:6
相关论文
共 11 条
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