Atropisomeric derivatives of 2′,6′-disubstituted (R)-11-phenylaporphine:: Selective serotonin 5-HT7 receptor antagonists

被引：41

作者：

Linnanen, T

Brisander, M

Unelius, L

Rosqvist, S

Nordvall, G

Hacksell, U

Johansson, AM

机构：

[1] Univ Uppsala, Uppsala Biomed Ctr, SE-75123 Uppsala, Sweden

[2] Univ Tromso, Inst Pharm, Dept Med Chem, N-9037 Tromso, Norway

[3] AstraZeneca R&D Sodertalje, Local Discovery Res Area CNS & Pain Control, SE-15185 Sodertalje, Sweden

[4] ACADIA Pharmaceut, San Diego, CA 92121 USA

[5] ACADIA Pharmaceut, DK-2600 Glostrup, Denmark

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 09期

关键词：

D O I：

10.1021/jm0108505

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1337 / 1340

页数：4

共 27 条

[11] Derivatives of (R)-1,11-methyleneaporphine:: Synthesis, structure, and interactions with G-protein coupled receptors [J].

Linnanen, T ;

Brisander, M ;

Unelius, L ;

Sundholm, G ;

Hacksell, U ;

Johansson, AM .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (07) :1339-1349

[12]

LINNANEN T, STUDIES SELECTIVE SE

[13] A novel, potent, and selective 5-HT7 antagonist:: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) [J].

Lovell, PJ ;

Bromidge, SM ;

Dabbs, S ;

Duckworth, DM ;

Forbes, IT ;

Jennings, AJ ;

King, FD ;

Middlemiss, DN ;

Rahman, SK ;

Saunders, DV ;

Collin, LL ;

Hagan, JJ ;

Riley, GJ ;

Thomas, DR .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (03) :342-345

[14]

MALMBERG A, 1993, MOL PHARMACOL, V43, P749

[15]

MISLOW K, 1965, INTRO STEREOCHEMISTR, P78

[16] PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOBORON COMPOUNDS [J].

MIYAURA, N ;

SUZUKI, A .

CHEMICAL REVIEWS, 1995, 95 (07) :2457-2483

[17] MACROMODEL - AN INTEGRATED SOFTWARE SYSTEM FOR MODELING ORGANIC AND BIOORGANIC MOLECULES USING MOLECULAR MECHANICS [J].

MOHAMADI, F ;

RICHARDS, NGJ ;

GUIDA, WC ;

LISKAMP, R ;

LIPTON, M ;

CAUFIELD, C ;

CHANG, G ;

HENDRICKSON, T ;

STILL, WC .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1990, 11 (04) :440-467

[18]

MOHELL N, 1995, N-S ARCH PHARMACOL, V351, P146

[19] Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK1 receptor antagonists:: Synthesis, antagonistic activity, and effects on bladder functions [J].

Natsugari, H ;

Ikeura, Y ;

Kamo, I ;

Ishimaru, T ;

Ishichi, Y ;

Fujishima, U ;

Tanaka, T ;

Kasahara, F ;

Kawada, M ;

Doi, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (19) :3982-3993

[20] SYNTHESIS, ASSIGNMENT OF ABSOLUTE-CONFIGURATION, AND RECEPTOR-BINDING STUDIES RELEVANT TO THE NEUROLEPTIC ACTIVITIES OF A SERIES OF CHIRAL 3-SUBSTITUTED CYPROHEPTADINE ATROPISOMERS [J].

RANDALL, WC ;

ANDERSON, PS ;

CRESSON, EL ;

HUNT, CA ;

LYON, TF ;

RITTLE, KE ;

REMY, DC ;

SPRINGER, JP ;

HIRSHFIELD, JM ;

HOOGSTEEN, K ;

WILLIAMS, M ;

RISLEY, EA ;

TOTARO, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (10) :1222-1230

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