Design and performance of GMR sensors for the detection of magnetic microbeads in biosensors

被引：316

作者：

Rife, JC

Miller, MM

Sheehan, PE

Tamanaha, CR

Tondra, M

Whitman, LJ

机构：

[1] USN, Res Lab, Washington, DC 20375 USA

[2] NVE Corp, Eden Prairie, MN 55344 USA

来源：

SENSORS AND ACTUATORS A-PHYSICAL | 2003年 / 107卷 / 03期

关键词：

biosensors; GMR; magnetoresistance; magnetic microbeads; magnetic sensors;

D O I：

10.1016/S0924-4247(03)00380-7

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We are developing a biosensor system, the Bead ARray Counter (BARC), based on the capture and detection of micron-sized, paramagnetic beads on a chip containing an array of giant magnetoresistive (GMR) sensors. Here we describe the design and performance of our current chip with 64 sensor zones, compare its performance with the previous chip design, and discuss a simple analytical model of the sensor micromagnetics. With assay-ready Dynal M-280 microbeads (2.8 mum diameter), our threshold for detection is approximately 10 beads per 200 mum-diameter sensor. Single beads made of solid Ni30Fe70 can easily be detected, but they must be made biocompatible. The relatively large size of our sensors helps to improve their practical sensitivity compared with other microsensor-based magnetic particle detectors. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：209 / 218

页数：10

共 29 条

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