Mutation rate and genotype variation of Ebola virus from Mali case sequences

被引：104

作者：

Hoenen, T. ^{[1
]}

Safronetz, D. ^{[1
]}

Groseth, A. ^{[1
]}

Wollenberg, K. R. ^{[2
]}

Koita, O. A. ^{[3
]}

Diarra, B. ^{[3
]}

Fall, I. S. ^{[4
]}

Haidara, F. C. ^{[5
]}

Diallo, F. ^{[5
]}

Sanogo, M. ^{[3
]}

Sarro, Y. S. ^{[3
]}

Kone, A. ^{[3
]}

Togo, A. C. G. ^{[3
]}

Traore, A. ^{[5
]}

Kodio, M. ^{[5
]}

Dosseh, A. ^{[6
]}

Rosenke, K. ^{[1
]}

de Wit, E. ^{[1
]}

Feldmann, F. ^{[7
]}

Ebihara, H. ^{[1
]}

Munster, V. J. ^{[1
]}

Zoon, K. C. ^{[8
]}

Feldmann, H. ^{[1
]}

Sow, S. ^{[5
]}

机构：

[1] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA

[2] NIAID, Bioinformat & Computat Biosci Branch, NIH, Bethesda, MD 20892 USA

[3] Univ Sci Tech & Technol Bamako, Ctr Res & Training HIV & TB, Bamako, Mali

[4] World Hlth Org Off, Bamako, Mali

[5] Minist Sante & Hyg Publ, Ctr Natl Appui Lutte Maladie, Ctr Dev Vaccins CVD Mali, Ctr Operat Urgence, Bamako, Mali

[6] WHO, Inter Country Support Team, Ouagadougou, Burkina Faso

[7] NIAID, Rocky Mt Vet Branch, Div Intramural Res, NIH, Hamilton, MT 59840 USA

[8] NIAID, Off Sci Director, NIH, Bethesda, MD 20895 USA

来源：

SCIENCE | 2015年 / 348卷 / 6230期

关键词：

OUTBREAK; TRANSMISSION; CONGO;

D O I：

10.1126/science.aaa5646

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The occurrence of Ebola virus (EBOV) in West Africa during 2013-2015 is unprecedented. Early reports suggested that in this outbreak EBOV is mutating twice as fast as previously observed, which indicates the potential for changes in transmissibility and virulence and could render current molecular diagnostics and countermeasures ineffective. We have determined additional full-length sequences from two clusters of imported EBOV infections into Mali, and we show that the nucleotide substitution rate (9.6 x 10(-4) substitutions per site per year) is consistent with rates observed in Central African outbreaks. In addition, overall variation among all genotypes observed remains low. Thus, our data indicate that EBOV is not undergoing rapid evolution in humans during the current outbreak. This finding has important implications for outbreak response and public health decisions and should alleviate several previously raised concerns.

引用

页码：117 / 119

页数：3

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